Since the times mankind took to agriculture, we have been improving our crops in order to get more yield. The tools of crop improvement are selective breeding of crops with desired characters, cross pollinating two related plants for desired characters followed by controlled self breeding. But this method of breeding has one major drawback. Nature has provided all organisms with genetic inability to breed freely with other species. An organism can breed only among those of same type. Due to this genetic blockage one species is unable to cross breed with another species. A species can breed among relatives of the same species only thus limiting the scope of improvement. There are some exceptions in nature to this like a cross between a donkey and mare is possible and results in a hinny, similarly across between a horse and jackass results in a mule but both hinny and mule are sterile.Advances in Molecular Biology and Biotechnology have provided us with tools to do away with this genetic blockage. Biotechnology has enabled us to produce organisms with desired characters crossing all limits of species except for religious, moral and ethical issues.